Abba J Kastin Selected Research

Leptin Receptors

8/2015	Role of Astrocytes in Leptin Signaling.
11/2013	Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.
10/2013	Saturable leptin transport across the BBB persists in EAE mice.
3/2013	Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.
3/2013	Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis.
3/2013	Protective role of astrocytic leptin signaling against excitotoxicity.
8/2012	Leptin action on nonneuronal cells in the CNS: potential clinical applications.
4/2012	Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.
12/2010	Role of astrocytic leptin receptor subtypes on leptin permeation across hCMEC/D3 human brain endothelial cells.
12/2009	Leptin receptor mRNA in rat brain astrocytes.

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Abba J Kastin Research Topics

Disease

25	Obesity 01/2016 - 12/2002
11	Inflammation (Inflammations) 08/2014 - 01/2003
6	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 08/2014 - 09/2009
5	Spinal Cord Injuries (Spinal Cord Injury) 01/2016 - 01/2003
5	Neuroinflammatory Diseases 02/2013 - 06/2008
4	Gliosis 01/2019 - 11/2010
4	Stroke (Strokes) 12/2007 - 04/2004
3	Sleep Deprivation 01/2017 - 06/2014
3	Autoimmune Diseases (Autoimmune Disease) 09/2009 - 04/2004
2	Schizophrenia (Dementia Praecox) 01/2022 - 01/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 09/2002
2	Memory Disorders (Memory Loss) 01/2019 - 11/2010
2	Sleep Wake Disorders 01/2017 - 06/2014
2	Multiple Sclerosis 11/2013 - 10/2013
2	Seizures (Absence Seizure) 03/2013 - 08/2012
2	Herpes Zoster 01/2012 - 10/2008
2	Astrocytoma (Pilocytic Astrocytoma) 12/2010 - 12/2009
2	Parkinson Disease (Parkinson's Disease) 01/2010 - 07/2009
2	Wounds and Injuries (Trauma) 12/2007 - 03/2003
1	Psychotic Disorders (Schizoaffective Disorder) 01/2020
1	Encephalitis (Encephalitis, Rasmussen) 01/2019
1	Cognitive Dysfunction 01/2019
1	Hyperglycemia 01/2016
1	Obstructive Sleep Apnea 06/2014
1	Disorders of Excessive Somnolence (Hypersomnia) 11/2013
1	Disease Progression 10/2013
1	Insulin Resistance 03/2013
1	Epilepsy (Aura) 03/2013
1	Body Weight (Weight, Body) 04/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2010
1	Sepsis (Septicemia) 06/2008
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2007
1	Leukemia 01/2007
1	Brain Ischemia (Cerebral Ischemia) 09/2006
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 03/2006
1	Ischemia 03/2006
1	Hyperphagia (Overeating) 12/2005
1	Pain (Aches) 12/2004
1	Neoplasms (Cancer) 05/2004
1	Cachexia 05/2004
1	Traumatic Brain Injuries (Traumatic Brain Injury) 03/2003
1	Dementia (Dementias) 09/2002
1	Amyloid angiopathy 09/2002
1	Diabetes Mellitus 02/2002

Drug/Important Bio-Agent (IBA)

24	LeptinIBA 01/2016 - 05/2006
12	Leptin ReceptorsIBA 08/2015 - 02/2008
10	CytokinesIBA 01/2016 - 03/2006
7	Peptides (Polypeptides)IBA 01/2016 - 12/2002
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2007 - 01/2003
6	Proteins (Proteins, Gene)FDA Link 01/2016 - 12/2005
5	Interleukin-15 (Interleukin 15)IBA 02/2013 - 07/2008
3	Tight Junction ProteinsIBA 01/2017 - 10/2008
3	AdipokinesIBA 08/2014 - 06/2007
3	LipopolysaccharidesIBA 03/2011 - 06/2008
3	InterleukinsIBA 02/2011 - 09/2009
2	Amyloid beta-PeptidesIBA 01/2019 - 09/2002
2	Pharmaceutical PreparationsIBA 01/2017 - 01/2008
2	UrocortinsIBA 01/2016 - 01/2007
2	Messenger RNA (mRNA)IBA 03/2013 - 12/2009
2	Minocycline (Cyclops)FDA LinkGeneric 06/2012 - 11/2010
2	MSH Release-Inhibiting Hormone (MIF-I)IBA 01/2010 - 07/2009
2	Therapeutic UsesIBA 01/2010 - 07/2009
1	Interleukin-15 Receptors (Interleukin 15 Receptor)IBA 01/2022
1	Immunologic Factors (Immunomodulators)IBA 01/2020
1	LipidsIBA 01/2020
1	Interleukin-15 Receptor alpha SubunitIBA 01/2019
1	tau Proteins (tau Protein)IBA 01/2019
1	proanthocyanidinIBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2017
1	SymportersIBA 01/2017
1	Autophagy-Related ProteinsIBA 01/2016
1	Galanin-Like PeptideIBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 06/2014
1	EnzymesIBA 01/2014
1	Cytoskeletal ProteinsIBA 01/2014
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2013
1	Triglycerides (Triacylglycerol)IBA 03/2013
1	Uncoupling Protein 1IBA 03/2013
1	Glutamic Acid (Glutamate)FDA Link 03/2013
1	Pilocarpine (Ocusert)FDA LinkGeneric 03/2013
1	C-Reactive ProteinIBA 01/2012
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2012
1	Carrier Proteins (Binding Protein)IBA 01/2012
1	fluorocitrateIBA 03/2011
1	gamma-Aminobutyric Acid (GABA)IBA 11/2010
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2010
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2010
1	Biological ProductsIBA 07/2009
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 07/2009
1	Glial Fibrillary Acidic ProteinIBA 10/2008
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2008
1	Indicators and Reagents (Reagents)IBA 01/2007
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 01/2007
1	salicylhydroxamic acid (SHAM)IBA 01/2007
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/2006
1	Agouti-Related ProteinIBA 12/2005
1	Interleukin-1beta (Interleukin 1 beta)IBA 03/2003
1	AntibodiesIBA 09/2002
1	Glucagon-Like Peptide 1 (GLP 1)IBA 02/2002

Therapy/Procedure

1	Continuous Positive Airway Pressure 06/2014